RMgmDB - Rodent Malaria genetically modified Parasites
Search for genetically modified parasite lines by:
Search database by RMgm ID
5528 results for:
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RMgm-533Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1122700; Gene model (P.falciparum): PF3D7_0623800; Gene product: tyrosine kinase-like protein, putative (tyrosine kinase like 5) Phenotype Liver stage;
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RMgm-534Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0927000; Gene model (P.falciparum): PF3D7_1121300; Gene product: tyrosine kinase-like protein (tyrosine kinase like 2) Phenotype Liver stage;
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RMgm-535Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0826900; Gene model (P.falciparum): PF3D7_0926100; Gene product: protein kinase, putative Phenotype Liver stage;
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RMgm-536Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1351500; Gene model (P.falciparum): PF3D7_1337800; Gene product: calcium-dependent protein kinase 5 (CDPK5) Phenotype No phenotype has been described
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RMgm-537Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0925200; Gene model (P.falciparum): PF3D7_1123100; Gene product: calcium-dependent protein kinase 7 (cdpk7) Phenotype No phenotype has been described
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RMgm-538Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1453400; Gene model (P.falciparum): PF3D7_1238900; Gene product: protein kinase 2 (pk2; protein kinase 2) Phenotype No phenotype has been described
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RMgm-539Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0829600; Gene model (P.falciparum): PF3D7_0928800; Gene product: serine/threonine protein kinase, putative Phenotype No phenotype has been described
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RMgm-540Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0311400; Gene model (P.falciparum): PF3D7_0214600; Gene product: serine/threonine protein kinase, putative Phenotype No phenotype has been described
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RMgm-541Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1313700; Gene model (P.falciparum): PF3D7_1450000; Gene product: serine/threonine protein kinase, putative Phenotype No phenotype has been described
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RMgm-542Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1413600; Gene model (P.falciparum): PF3D7_1315100; Gene product: serine/threonine protein kinase PK9 Phenotype No phenotype has been described
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RMgm-543Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0835600; Gene model (P.falciparum): PF3D7_0934800; Gene product: cAMP-dependent protein kinase catalytic subunit (pka) Phenotype No phenotype has been described
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RMgm-544Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1008200; Gene model (P.falciparum): PF3D7_1436600; Gene product: cGMP-dependent protein kinase (PKG) Phenotype No phenotype has been described
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RMgm-545Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1460000; Gene model (P.falciparum): PF3D7_1246900; Gene product: RAC-beta serine/threonine protein kinase (pkb) Phenotype No phenotype has been described
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RMgm-546Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0926400; Gene model (P.falciparum): PF3D7_1121900; Gene product: serine/threonine protein kinase, putative Phenotype No phenotype has been described
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RMgm-547Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0407400; Gene model (P.falciparum): PF3D7_0309200; Gene product: serine/threonine protein kinase, putative (ARK2) Phenotype No phenotype has been described
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RMgm-548Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1133100; Gene model (P.falciparum): PF3D7_1356800; Gene product: serine/threonine protein kinase, putative Phenotype No phenotype has been described
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RMgm-549Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0903800; Gene model (P.falciparum): PF3D7_1145200; Gene product: serine/threonine protein kinase, putative Phenotype No phenotype has been described
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RMgm-550Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0104100; Gene model (P.falciparum): PF3D7_0605300; Gene product: serine/threonine protein kinase | aurora-related kinase 1 Phenotype No phenotype has been described
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RMgm-551Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0615800; Gene model (P.falciparum): PF3D7_0718100; Gene product: exported serine/threonine protein kinase (est) Phenotype No phenotype has been described
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RMgm-552Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0912100; Gene model (P.falciparum): PF3D7_1136500; Gene product: casein kinase 1 (ck1) Phenotype No phenotype has been described
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RMgm-553Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1212800; Gene model (P.falciparum): PF3D7_1014400; Gene product: MO15-related protein kinase (mrk) Phenotype No phenotype has been described
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RMgm-554Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0719900; Gene model (P.falciparum): PF3D7_0417800; Gene product: cdc2-related protein kinase 1 (crk-1) Phenotype No phenotype has been described
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RMgm-555Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0717300; Gene model (P.falciparum): PF3D7_0415300; Gene product: cdc2-related protein kinase 3 (crk-3; cdc2-related protein kinase 3) Phenotype No phenotype has been described
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RMgm-556Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1230200; Gene model (P.falciparum): PF3D7_0615500; Gene product: cdc2-related protein kinase 5 (crk-5; cdc2-related protein kinase 5) Phenotype No phenotype has been described
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RMgm-557Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1350900; Gene model (P.falciparum): PF3D7_1337100; Gene product: protein kinase 6 (crk-6, pk6) Phenotype No phenotype has been described
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RMgm-558Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0938600; Gene model (P.falciparum): PF3D7_1108400; Gene product: casein kinase 2, alpha subunit (ck2) Phenotype No phenotype has been described
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RMgm-559Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0410400; Gene model (P.falciparum): PF3D7_0312400; Gene product: glycogen synthase kinase 3 (gsk3) Phenotype No phenotype has been described
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RMgm-560Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1414500; Gene model (P.falciparum): PF3D7_1316000; Gene product: protein kinase, putative Phenotype No phenotype has been described
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RMgm-561Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1309200; Gene model (P.falciparum): PF3D7_1445400; Gene product: protein serine/threonine kinase-1 (Lammer; PfCLK-1) Phenotype No phenotype has been described
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RMgm-562Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0933000; Gene model (P.falciparum): PF3D7_1114700; Gene product: serine/threonine protein kinase, putative (prk4) Phenotype No phenotype has been described
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RMgm-563Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0808000; Gene model (P.falciparum): PF3D7_0317200; Gene product: cdc2-related protein kinase 4 (crk-4; cdc2-related protein kinase 4) Phenotype No phenotype has been described
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RMgm-564Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1443000; Gene model (P.falciparum): PF3D7_1228300; Gene product: NIMA related kinase 1 (nek-1) Phenotype No phenotype has been described
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RMgm-565Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0600600; Gene model (P.falciparum): PF3D7_1201600; Gene product: NIMA related kinase 3 (nek-3; NIMA related kinase 3) Phenotype No phenotype has been described
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RMgm-566Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1126900; Gene model (P.falciparum): PF3D7_0628200; Gene product: protein kinase PK4 | eukaryotic translation initiation factor 2-alpha kinase (pk4) Phenotype No phenotype has been described
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RMgm-567Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0901100; Gene model (P.falciparum): PF3D7_1148000; Gene product: serine/threonine protein kinase, putative Phenotype No phenotype has been described
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RMgm-568Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1305200; Gene model (P.falciparum): PF3D7_1441300; Gene product: serine/threonine protein kinase, putative Phenotype No phenotype has been described
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RMgm-569Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1421600; Gene model (P.falciparum): PF3D7_0715300; Gene product: calcium/calmodulin-dependent protein kinase, putative Phenotype No phenotype has been described
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RMgm-570Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1228800; Gene model (P.falciparum): Not available; Gene product: protein kinase, putative (tkl6) Phenotype No phenotype has been described
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RMgm-571Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0308500; Gene model (P.falciparum): PF3D7_0211700; Gene product: tyrosine kinase-like protein, putative (tkl1) Phenotype No phenotype has been described
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RMgm-572Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1362100; Gene model (P.falciparum): PF3D7_1349300; Gene product: tyrosine kinase-like protein (tkl3) Phenotype No phenotype has been described
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RMgm-573Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1010900; Gene model (P.falciparum): PF3D7_1433900; Gene product: protein kinase, putative (tkl4) Phenotype No phenotype has been described
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RMgm-574Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0805600; Gene model (P.falciparum): PF3D7_0708300; Gene product: EKC/KEOPS complex subunit BUD32 Phenotype No phenotype has been described
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RMgm-575Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1217100; Gene model (P.falciparum): PF3D7_0321400; Gene product: protein kinase, putative Phenotype No phenotype has been described
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RMgm-576Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0940100; Gene model (P.falciparum): PF3D7_1106800; Gene product: protein kinase, putative Phenotype No phenotype has been described
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RMgm-577Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0826800; Gene model (P.falciparum): PF3D7_0926000; Gene product: protein kinase, putative Phenotype No phenotype has been described
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RMgm-578Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1345900; Gene model (P.falciparum): PF3D7_1331000; Gene product: protein kinase, putative Phenotype No phenotype has been described
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RMgm-579Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0621500; Gene model (P.falciparum): PF3D7_0724000; Gene product: Rab GTPase activator and protein kinase, putative Phenotype No phenotype has been described
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RMgm-580Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1445600; Gene model (P.falciparum): PF3D7_1230900; Gene product: serine/threonine protein kinase RIO1, putative (rio1) Phenotype No phenotype has been described
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RMgm-581Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0521400; Gene model (P.falciparum): PF3D7_0420100; Gene product: serine/threonine protein kinase RIO2 (rio2) Phenotype No phenotype has been described
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RMgm-582Malaria parasite P. yoelii Genotype Transgene Transgene Plasmodium: Gene model: PY17X_1446500; Gene model (P.falciparum): PF3D7_1229400; Gene product: macrophage migration inhibitory factor (MIF)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Insertion locus: Gene model: Not available; Gene product: Not available (small subunit ribosomal rna gene (c-type unit))
Phenotype Asexual bloodstage;
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RMgm-583Malaria parasite P. yoelii Genotype Transgene Transgene Plasmodium: Gene model: PY17X_1446500; Gene model (P.falciparum): PF3D7_1229400; Gene product: macrophage migration inhibitory factor (MIF)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PY04370; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase (dhfr/ts)
Phenotype Asexual bloodstage;
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RMgm-584Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0606700; Gene model (P.falciparum): PF3D7_1208200; Gene product: cysteine repeat modular protein 3 (CRMP3) Phenotype Oocyst; Sporozoite; Liver stage;
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RMgm-585Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1300800; Gene model (P.falciparum): PF3D7_1475400; Gene product: cysteine repeat modular protein 4 (CRMP4) Phenotype Oocyst; Sporozoite; Liver stage;
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RMgm-586Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0824700; Gene model (P.falciparum): PF3D7_0923800; Gene product: thioredoxin reductase (TrxR) Phenotype Oocyst; Sporozoite; Liver stage;
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RMgm-587Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1023400; Gene model (P.falciparum): PF3D7_1419800; Gene product: glutathione reductase (GR) Phenotype Asexual bloodstage; Oocyst; Sporozoite; Liver stage;
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RMgm-588Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0917400; Gene model (P.falciparum): PF3D7_1130800; Gene product: armadillo repeat protein PF16, putative (PF16) Phenotype Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite; Liver stage;
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RMgm-589Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0917400; Gene model (P.falciparum): PF3D7_1130800; Gene product: armadillo repeat protein PF16, putative (PF16)
Name tag: GFP
Phenotype Gametocyte/Gamete; Fertilization and ookinete;
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RMgm-590Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: HIV-1 gag
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Phenotype Asexual bloodstage;
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RMgm-591Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1233500; Gene model (P.falciparum): PF3D7_0518700; Gene product: mRNA-binding protein PUF1 (Pumilio1) Disrupted Gene model (rodent): PBANKA_0719200; Gene model (P.falciparum): PF3D7_0417100; Gene product: mRNA-binding protein PUF2 (Pumilio2) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Fertilization and ookinete; Sporozoite; Liver stage;
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RMgm-592Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1002200; Gene model (P.falciparum): PF3D7_0404500; Gene product: 6-cysteine protein (P36p; Pb36p; P52) Transgene Transgene not Plasmodium: GFP
Promoter: Gene model: PBANKA_0711900; Gene model (P.falciparum): PF3D7_0818900; Gene product: heat shock protein 70 (HSP70)
3'UTR: Gene model: PBANKA_1002200; Gene product: 6-cysteine protein (P36p; Pb36p; P52)
Insertion locus: Gene model: PBANKA_1002200; Gene product: 6-cysteine protein (P36p; Pb36p; P52)
Phenotype Liver stage;
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RMgm-593Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: GFP
Promoter: Gene model: PBANKA_1003000; Gene model (P.falciparum): PF3D7_0405300; Gene product: liver specific protein 2, putative | sequestrin | 6-cysteine protein (LISP2)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Insertion locus: Gene model: Not available; Gene product: Not available (small subunit ribosomal rna gene (c-type and/or d-type unit))
Phenotype Liver stage;
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RMgm-594Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: firefly luciferase
Promoter: Gene model: PBANKA_1003000; Gene model (P.falciparum): PF3D7_0405300; Gene product: liver specific protein 2, putative | sequestrin | 6-cysteine protein (LISP2)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Insertion locus: Gene model: Not available; Gene product: Not available (small subunit ribosomal rna gene (c-type and/or d-type unit))
Transgene Transgene not Plasmodium: Renilla luciferase
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Insertion locus: Gene model: Not available; Gene product: Not available (small subunit ribosomal rna gene (c-type and/or d-type unit))
Phenotype Liver stage;
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RMgm-595Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: firefly luciferase
Promoter: Gene model: PBANKA_0402000; Gene model (P.falciparum): PF3D7_0303400; Gene product: palmitoyltransferase DHHC1
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Insertion locus: Gene model: Not available; Gene product: Not available (small subunit ribosomal rna gene (c-type and/or d-type unit))
Transgene Transgene not Plasmodium: Renilla luciferase
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Insertion locus: Gene model: Not available; Gene product: Not available (small subunit ribosomal rna gene (c-type and/or d-type unit))
Phenotype Asexual bloodstage; Oocyst; Sporozoite; Liver stage;
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RMgm-596Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0519000; Gene model (P.falciparum): Not available; Gene product: S-antigen, putative Phenotype No phenotype has been described
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RMgm-597Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1002100; Gene model (P.falciparum): PF3D7_0404400; Gene product: 6-cysteine protein (P36) Disrupted Gene model (rodent): PBANKA_1002200; Gene model (P.falciparum): PF3D7_0404500; Gene product: 6-cysteine protein (P36p; Pb36p; P52) Transgene Transgene not Plasmodium: A fusion of GFP (gfp-mu3) and Luciferase Firefly (LucIAV)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Liver stage;
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RMgm-598Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1125100; Gene model (P.falciparum): PF3D7_0626300; Gene product: 3-oxoacyl-acyl-carrier protein synthase I/II (FabB/F) Phenotype Sporozoite; Liver stage;
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RMgm-599Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1125100; Gene model (P.falciparum): PF3D7_0626300; Gene product: 3-oxoacyl-acyl-carrier protein synthase I/II (FabB/F) Transgene Transgene not Plasmodium: A fusion of GFP (gfp-mu3) and Luciferase Firefly (LucIAV)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Sporozoite; Liver stage;
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RMgm-600Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1436600; Gene model (P.falciparum): PF3D7_1221400; Gene product: inner membrane complex protein 1h, putative (Inner membrane complex protein 1h; IMC1h)
Name tag: EGFP
Phenotype Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-601Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1436600; Gene model (P.falciparum): PF3D7_1221400; Gene product: inner membrane complex protein 1h, putative (Inner membrane complex protein 1h; IMC1h) Transgene Transgene not Plasmodium: EGFP
Promoter: Gene model: PBANKA_1436600; Gene model (P.falciparum): PF3D7_1221400; Gene product: inner membrane complex protein 1h, putative (Inner membrane complex protein 1h; IMC1h)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_1436600; Gene product: inner membrane complex protein 1h (IMC1h)
Phenotype Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-602Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0907100; Gene model (P.falciparum): PF3D7_1141900; Gene product: inner membrane complex protein 1b, putative (IMC1b, inner membrane complex protein 1b) Disrupted Gene model (rodent): PBANKA_1436600; Gene model (P.falciparum): PF3D7_1221400; Gene product: inner membrane complex protein 1h, putative (IMC1h, inner membrane complex protein 1h) Transgene Transgene not Plasmodium: EGFP
Promoter: Gene model: PBANKA_0907100; Gene model (P.falciparum): PF3D7_1141900; Gene product: inner membrane complex protein 1b, putative (IMC1b, inner membrane complex protein 1b)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0907100; Gene product: inner membrane complex protein 1b (IMC1b)
Transgene Transgene not Plasmodium: EGFP
Promoter: Gene model: PBANKA_1436600; Gene model (P.falciparum): PF3D7_1221400; Gene product: inner membrane complex protein 1h, putative (Inner membrane complex protein 1h; IMC1h)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_1436600; Gene product: inner membrane complex protein 1h (IMC1h)
Phenotype Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-603Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0302500; Gene model (P.falciparum): PF3D7_0204700; Gene product: hexose transporter (hexose transporter 1, HT1; PfHT1, PfHT, PbHT, PbHT1)
Name tag: HA-tag
Phenotype Asexual bloodstage; Liver stage;
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RMgm-604Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_0302500; Gene model (P.falciparum): PF3D7_0204700; Gene product: hexose transporter (hexose transporter 1, HT1; PfHT1, PfHT, PbHT, PbHT1)
Details mutation: The endogenous pbht1 gene is replaced with the P. falciparum ortholog, pfht1 (PFB0210c)
Phenotype Asexual bloodstage;
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RMgm-605Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1212600; Gene model (P.falciparum): PF3D7_1014200; Gene product: male gamete fusion factor HAP2, putative (HAP2; HAPLESS2; GCS1, generative cell specific 1)
Details mutation: The HAP2-GCS1 functional domain (amino acids 345-404) of hap2/gcs1 deleted
Phenotype Fertilization and ookinete;
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RMgm-606Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1212600; Gene model (P.falciparum): PF3D7_1014200; Gene product: male gamete fusion factor HAP2, putative (HAP2; HAPLESS2; GCS1, generative cell specific 1)
Details mutation: The C-terminal region (downstream from the TM domain; amino acids 712-728) of hap2/gcs1 deleted
Phenotype Fertilization and ookinete;
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RMgm-607Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1212600; Gene model (P.falciparum): PF3D7_1014200; Gene product: male gamete fusion factor HAP2, putative (HAP2; HAPLESS2; GCS1, generative cell specific 1)
Details mutation: The TM domain and the entire C-terminal region downstream from the TM deleted (amino acids 680-827).
Phenotype Fertilization and ookinete;
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RMgm-608Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_0403200; Gene model (P.falciparum): PF3D7_0304600; Gene product: circumsporozoite (CS) protein (CS, CSP)
Details mutation: deletion of region 1 (amino acids KLKQP)
Phenotype Sporozoite; Liver stage;
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RMgm-609Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_0403200; Gene model (P.falciparum): PF3D7_0304600; Gene product: circumsporozoite (CS) protein (CS, CSP)
Details mutation: deletion of entire N terminus excluding the signal sequence (including region I)
Phenotype Oocyst; Sporozoite; Liver stage;
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RMgm-610Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1219500; Gene model (P.falciparum): PF3D7_0709000; Gene product: chloroquine resistance transporter (CRT)
Details mutation: crt of P. berghei replaced by the (chlorquine-sensitive, HB3) P. falciparum crt gene (MAL7P1.27)
Phenotype Asexual bloodstage; Gametocyte/Gamete; Oocyst;
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RMgm-611Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1219500; Gene model (P.falciparum): PF3D7_0709000; Gene product: chloroquine resistance transporter (CRT)
Details mutation: crt of P. berghei replaced by the (chloroquine-resistant, 7G8) P. falciparum crt gene (MAL7P1.27)
Phenotype Asexual bloodstage; Gametocyte/Gamete; Oocyst;
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RMgm-612Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1219500; Gene model (P.falciparum): PF3D7_0709000; Gene product: chloroquine resistance transporter (CRT) Phenotype No phenotype has been described
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RMgm-613Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_0403200; Gene model (P.falciparum): PF3D7_0304600; Gene product: circumsporozoite (CS) protein (CSP)
Details mutation: the natural H-2K(d) restricted epitope SYIPSAEKI mutated to SIINFEKL, an H-2K(b) restricted epitope
Phenotype Sporozoite; Liver stage;
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RMgm-614Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_0403200; Gene model (P.falciparum): PF3D7_0304600; Gene product: circumsporozoite (CS) protein (CSP)
Details mutation: Mutated pexel/VTS motif and the H-2K(d) epitope SYIPSAEKI mutated to the H-2K (b)epitope SIINFEKL
Phenotype Sporozoite; Liver stage;
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RMgm-615Malaria parasite P. yoelii Genotype Disrupted Gene model (rodent): PY17X_1468100; Gene model (P.falciparum): Not available; Gene product: Not available (235EBP-1; Py235EBP-1; erythrocyte binding protein 1) Phenotype Asexual bloodstage;
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RMgm-616Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1233500; Gene model (P.falciparum): PF3D7_0518700; Gene product: mRNA-binding protein PUF1 (Pumilio1) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Oocyst; Sporozoite;
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RMgm-617Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0719200; Gene model (P.falciparum): PF3D7_0417100; Gene product: mRNA-binding protein PUF2 (Pumilio2) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Gametocyte/Gamete; Sporozoite; Liver stage;
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RMgm-618Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1211900; Gene model (P.falciparum): PF3D7_1013500; Gene product: phosphoinositide-specific phospholipase C (PI-PLC) Phenotype No phenotype has been described
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RMgm-619Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0715500; Gene model (P.falciparum): PF3D7_0413500; Gene product: phosphoglucomutase-2 (PGM2) Phenotype No phenotype has been described
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RMgm-620Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0715500; Gene model (P.falciparum): PF3D7_0413500; Gene product: phosphoglucomutase-2 (PGM2)
Name tag: GFP
Phenotype Asexual bloodstage; Fertilization and ookinete;
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RMgm-621Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1116000; Gene model (P.falciparum): PF3D7_0616500; Gene product: TRAP-like protein (TLP) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Sporozoite; Liver stage;
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RMgm-622Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_0412900; Gene model (P.falciparum): PF3D7_0315200; Gene product: circumsporozoite- and TRAP-related protein (CTRP; circumsporozoite- and thrombospondin-related adhesive protein (TRAP)-related protein (CTRP))
Details mutation: Mutated ctrp lacking the seven tandem thrombospondin type I repeat-like (TS) domains
Phenotype No phenotype has been described
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RMgm-623Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_0412900; Gene model (P.falciparum): PF3D7_0315200; Gene product: circumsporozoite- and TRAP-related protein (CTRP; circumsporozoite- and thrombospondin-related adhesive protein (TRAP)-related protein (CTRP))
Details mutation: Mutated ctrp lacking the six A-domains
Phenotype Fertilization and ookinete; Oocyst;
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RMgm-624Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0208300; Gene model (P.falciparum): PF3D7_0104800; Gene product: novel putative transporter 1, putative (Novel Putative Transporter, NPT1)
Name tag: HA
Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Asexual bloodstage; Gametocyte/Gamete;
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RMgm-626Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0208300; Gene model (P.falciparum): PF3D7_0104800; Gene product: novel putative transporter 1, putative (Novel Putative Transporter, NPT1) Phenotype Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-628Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0932000; Gene model (P.falciparum): PF3D7_1116000; Gene product: rhoptry neck protein 4 (RON4)
Name tag: mCherry
Phenotype Asexual bloodstage; Sporozoite;
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RMgm-629Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0208300; Gene model (P.falciparum): PF3D7_0104800; Gene product: novel putative transporter 1, putative (Novel Putative Transporter, NPT1) Transgene Transgene not Plasmodium: RFP
Promoter: Gene model: PBANKA_1319500; Gene model (P.falciparum): PF3D7_1455800; Gene product: LCCL domain-containing protein (LAP4; LCCL/lectin adhesive-like protein 4; CCp2)
3'UTR: Gene model: PBANKA_1359600; Gene product: transmission blocking target antigen precursor 6-cysteine protein (P48/45)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Transgene Transgene not Plasmodium: GFP (gfp-mut3)
Promoter: Gene model: PBANKA_0416100; Gene model (P.falciparum): PF3D7_0905300; Gene product: dynein heavy chain, putative
3'UTR: Gene model: PBANKA_1010600; Gene product: calmodulin, putative (cam)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-630Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0816000; Gene model (P.falciparum): PF3D7_0915000; Gene product: type II NADH:ubiquinone oxidoreductase (NDH2) Transgene Transgene not Plasmodium: GFP
Promoter: Gene model: PBANKA_0816000; Gene model (P.falciparum): PF3D7_0915000; Gene product: type II NADH:ubiquinone oxidoreductase (NDH2)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0816000; Gene product: type II NADH:ubiquinone oxidoreductase (NDH2)
Phenotype Oocyst; Sporozoite;
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RMgm-631Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0816000; Gene model (P.falciparum): PF3D7_0915000; Gene product: type II NADH:ubiquinone oxidoreductase (NDH2)
Name tag: mCherry
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite; Liver stage;
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RMgm-632Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1030100; Gene model (P.falciparum): PF3D7_1412500; Gene product: actin II (actin2) Phenotype Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-633Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1030100; Gene model (P.falciparum): PF3D7_1412500; Gene product: actin II (actin2)
Name tag: GFP
Phenotype Gametocyte/Gamete;
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RMgm-634Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: GFP
Promoter: Gene model: PBANKA_1030100; Gene model (P.falciparum): PF3D7_1412500; Gene product: actin II (actin2)
3'UTR: Gene model: PBANKA_1340000; Gene product: dihydrofolate synthase/folylpolyglutamate synthase, putative (DHFS-FPGS)
Insertion locus: Gene model: Not available; Gene product: Not available
Phenotype Gametocyte/Gamete;