Mutant/mutation
The mutant lacks expression of thioredoxin peroxidase 2 (TPx-2).

Protein (function)
Malaria parasites possess six peroxidases localized in the cytoplasm, mitochondrion, apicoplast and nucleus: a 1-Cys Prx, two typical 2-Cys Prxs, a 1-Cys antioxidant protein (AOP), a Prx family with unusual biochemical characteristics and a glutathione (GSH) peroxidase-like thioredoxin peroxidase (TPxGl). Since malaria parasites do not possess catalase and genuine GSH peroxidase in their genome, it is considered that GSH itself is the major redox buffer for transient H2O2 exposure and the basal peroxide flux in the cell is dealt with by the Trx system.
 2-Cys Prxs have been found to act as a terminal peroxidase that reduces hydrogen peroxide and organic hydroperoxides with the use of electrons donated by the thioredoxin (Trx) system. Plasmodium contains 1-Cys Prx and two typical 2-Cys Prxs; TPx-1 (cytosolic) and TPx-2 (mitochondrial); see also 'Additional information').

Phenotype
Phenotype analyses indicate that TPx-2 is not essential for blood stage development and development of (gametocytes, ookinetes and) oocysts.

Additional information
In most eukaryotic organisms, redox-active enzymes, such as catalase, superoxide dismutase, and peroxidases as well as an enzymatic cascade that generates reduced electron donors, i.e. glutathione (GSH) and thioredoxin (Trx), sustain the cellular redox homeostasis. This redox network is split into two major arms, the GSH and the Trx system, that serve complementary functions in antioxidant defence and DNA synthesis. The malarial parasite Plasmodium lacks two central antioxidant enzymes: (i) catalase that typically detoxifies hydrogen peroxide and (ii) a classical glutathione peroxidase, a selenoenyzme that reduces lipid hydroperoxides to their alcohols. This apparent deficiency  underscores the possible central importance of the thioredoxin system in the parasite. 

See also mutant RMgm-206 which lacks expression of the 2-Cys peroxiredoxin, thioredoxin peroxidase 1 (TPx-1)

Other mutants
RMgm-206: A mutant lacking expression of thioredoxin peroxidase 1 (TPx-1)
RMgm-586: A mutant lacking expression of thioredoxin reductase (TrxR)