RMgmDB - Rodent Malaria genetically modified Parasites
Search for genetically modified parasite lines by:
Search database by RMgm ID
4890 results for:
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RMgm-1043Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1462200; Gene model (P.falciparum): PF3D7_1249300; Gene product: protein phosphatase PPM4, putative (PPM4) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype No phenotype has been described
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RMgm-1044Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1427200; Gene model (P.falciparum): PF3D7_0813000; Gene product: conserved Plasmodium protein, unknown function (PPM5) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Oocyst; Sporozoite; Liver stage;
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RMgm-1045Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1427000; Gene model (P.falciparum): PF3D7_0810500; Gene product: protein phosphatase PPM7, putative (PPM7) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype No phenotype has been described
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RMgm-1046Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0913400; Gene model (P.falciparum): PF3D7_1135100; Gene product: protein phosphatase PPM8, putative (PPM8) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype No phenotype has been described
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RMgm-1047Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1318800; Gene model (P.falciparum): PF3D7_1455100; Gene product: protein tyrosine phosphatase, putative (PTP1) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype No phenotype has been described
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RMgm-1048Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1223900; Gene model (P.falciparum): Not available; Gene product: protein tyrosine phosphatase (PTP2) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype No phenotype has been described
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RMgm-1049Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1346500; Gene model (P.falciparum): PF3D7_1331600; Gene product: protein tyrosine phosphatase-like protein, putative (PTPLA; 3-hydroxyacyl-CoA dehydratase; DEH) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Oocyst; Sporozoite; Liver stage;
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RMgm-1050Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1403300; Gene model (P.falciparum): Not available; Gene product: NLI interacting factor-like phosphatase (NIF1) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype No phenotype has been described
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RMgm-1051Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0826200; Gene model (P.falciparum): PF3D7_0925400; Gene product: protein phosphatase-beta Phenotype No phenotype has been described
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RMgm-1052Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1227400; Gene model (P.falciparum): PF3D7_0802800; Gene product: serine/threonine protein phosphatase 2B catalytic subunit A (CNA) Phenotype No phenotype has been described
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RMgm-1053Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0828500; Gene model (P.falciparum): PF3D7_0927700; Gene product: serine/threonine protein phosphatase 4, putative Phenotype No phenotype has been described
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RMgm-1055Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0412100; Gene model (P.falciparum): PF3D7_1414400; Gene product: serine/threonine protein phosphatase PP1 Phenotype No phenotype has been described
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RMgm-1056Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1020100; Gene model (P.falciparum): PF3D7_1423300; Gene product: serine/threonine protein phosphatase 7 (PP7) Phenotype No phenotype has been described
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RMgm-1057Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0502500; Gene model (P.falciparum): PF3D7_1018200; Gene product: serine/threonine protein phosphatase 8, putative Phenotype No phenotype has been described
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RMgm-1058Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1407700; Gene model (P.falciparum): PF3D7_1309200; Gene product: protein phosphatase PPM6, putative Phenotype No phenotype has been described
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RMgm-1059Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1234900; Gene model (P.falciparum): PF3D7_0520100; Gene product: protein phosphatase PPM9, putative Phenotype No phenotype has been described
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RMgm-1060Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0407200; Gene model (P.falciparum): PF3D7_0309000; Gene product: dual specificity protein phosphatase (YVH1) Phenotype No phenotype has been described
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RMgm-1061Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0934500; Gene model (P.falciparum): PF3D7_1113100; Gene product: protein tyrosine phosphatase (PRL) Phenotype No phenotype has been described
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RMgm-1062Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1115500; Gene model (P.falciparum): PF3D7_0515900; Gene product: NLI interacting factor-like phosphatase, putative Phenotype No phenotype has been described
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RMgm-1063Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1132000; Gene model (P.falciparum): PF3D7_1355700; Gene product: NLI interacting factor-like phosphatase, putative Phenotype No phenotype has been described
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RMgm-1064Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1211100; Gene model (P.falciparum): PF3D7_1012700; Gene product: NLI interacting factor-like phosphatase, putative Phenotype No phenotype has been described
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RMgm-1065Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0211000; Gene model (P.falciparum): PF3D7_0726900; Gene product: mitochondrial import inner membrane translocase subunit TIM50, putative (TIM50) Phenotype No phenotype has been described
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RMgm-1066Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0826200; Gene model (P.falciparum): PF3D7_0925400; Gene product: protein phosphatase-beta (PPP2)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1067Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1227400; Gene model (P.falciparum): PF3D7_0802800; Gene product: serine/threonine protein phosphatase 2B catalytic subunit A (CNA; PPP3)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1068Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0828500; Gene model (P.falciparum): PF3D7_0927700; Gene product: serine/threonine protein phosphatase 4, putative (PPP4)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1069Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1131900; Gene model (P.falciparum): PF3D7_1355500; Gene product: serine/threonine protein phosphatase 5 (PP5; PPP5)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1070Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0412100; Gene model (P.falciparum): PF3D7_0314400; Gene product: serine/threonine protein phosphatase 6, putative (PPP6)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete;
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RMgm-1071Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1020100; Gene model (P.falciparum): PF3D7_1423300; Gene product: serine/threonine protein phosphatase 7 (PP7; PPP7)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1072Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0502500; Gene model (P.falciparum): PF3D7_1018200; Gene product: serine/threonine protein phosphatase 8, putative (PPP8)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1073Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1332400; Gene model (P.falciparum): PF3D7_1469200; Gene product: shewanella-like protein phosphatase 1, putative (SHLP1)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-1074Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0604700; Gene model (P.falciparum): PF3D7_1206000; Gene product: shewanella-like protein phosphatase 2 (SHLP2)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1075Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1007700; Gene model (P.falciparum): PF3D7_0410300; Gene product: protein phosphatase PPM1, putative (PPM1)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1076Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0910200; Gene model (P.falciparum): PF3D7_1138500; Gene product: protein phosphatase 2C | protein phosphatase PPM2 (PP2C; PPM2)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1077Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1318700; Gene model (P.falciparum): PF3D7_1455000; Gene product: protein phosphatase PPM3, putative (PPM3)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1078Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1462200; Gene model (P.falciparum): PF3D7_1249300; Gene product: protein phosphatase PPM4, putative (PPM4)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1079Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1427200; Gene model (P.falciparum): PF3D7_0810300; Gene product: protein phosphatase PPM5, putative (PPM5)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1080Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1407700; Gene model (P.falciparum): PF3D7_1309200; Gene product: protein phosphatase PPM6, putative (PPM6)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1081Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0913400; Gene model (P.falciparum): PF3D7_1135100; Gene product: protein phosphatase PPM8, putative (PPM7)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1082Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0913400; Gene model (P.falciparum): PF3D7_1135100; Gene product: protein phosphatase PPM8, putative (PPM8)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1083Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1318800; Gene model (P.falciparum): PF3D7_1455100; Gene product: protein tyrosine phosphatase, putative (PTP1)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1084Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1223900; Gene model (P.falciparum): Not available; Gene product: protein tyrosine phosphatase (PTP2)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete;
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RMgm-1085Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0407200; Gene model (P.falciparum): PF3D7_0309000; Gene product: dual specificity protein phosphatase (YVH1)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1086Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0934500; Gene model (P.falciparum): PF3D7_1113100; Gene product: protein tyrosine phosphatase (PRL)
Name tag: GFP
Phenotype Gametocyte/Gamete;
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RMgm-1087Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1346500; Gene model (P.falciparum): PF3D7_1331600; Gene product: protein tyrosine phosphatase-like protein, putative (PTPLA; 3-hydroxyacyl-CoA dehydratase; DEH)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1088Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1403300; Gene model (P.falciparum): Not available; Gene product: NLI interacting factor-like phosphatase (NIF1)
Name tag: GFP
Phenotype Gametocyte/Gamete;
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RMgm-1089Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1115500; Gene model (P.falciparum): PF3D7_0515900; Gene product: NLI interacting factor-like phosphatase, putative (NIF2)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1090Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1132000; Gene model (P.falciparum): PF3D7_1355700; Gene product: NLI interacting factor-like phosphatase, putative (NIF3)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1091Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1211100; Gene model (P.falciparum): PF3D7_1012700; Gene product: NLI interacting factor-like phosphatase, putative (NIF4)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1092Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0211000; Gene model (P.falciparum): PF3D7_0726900; Gene product: mitochondrial import inner membrane translocase subunit TIM50, putative (TIM50)
Name tag: GFP
Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst;
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RMgm-1093Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0517600; Gene model (P.falciparum): PF3D7_1033800; Gene product: plasmepsin VII Transgene Transgene not Plasmodium: GFP
Promoter: Gene model: PBANKA_0711900; Gene model (P.falciparum): PF3D7_0818900; Gene product: heat shock protein 70 (HSP70)
3'UTR: Gene model: PBANKA_0711900; Gene product: heat shock protein 70 (HSP70)
Replacement locus: Gene model: PBANKA_0517600; Gene product: plasmepsin VII
Phenotype No phenotype has been described
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RMgm-1094Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1008200; Gene model (P.falciparum): PF3D7_1436600; Gene product: cGMP-dependent protein kinase (PKG)
Details mutation: The P. berghei pkg gene replaced by the P. falciparum pkg gene
Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-1095Malaria parasite P. yoelii Genotype Disrupted Gene model (rodent): PY17X_0305700; Gene model (P.falciparum): Not available; Gene product: serine repeat antigen 1 (SERA1) Phenotype No phenotype has been described
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RMgm-1096Malaria parasite P. yoelii Genotype Tagged Gene model (rodent): PY17X_0946500; Gene model (P.falciparum): Not available; Gene product: early transcribed membrane protein (ETRAMP)
Name tag: GFP
Phenotype Asexual bloodstage;
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RMgm-1097Malaria parasite P. yoelii Genotype Mutated Gene model (rodent): PY17X_0712100; Gene model (P.falciparum): Not available; Gene product: heat shock protein, putative (HSP70)
Details mutation: Silent mutations introduced into the hsp70 gene using CRISPR/Cas9 technology
Phenotype No phenotype has been described
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RMgm-1098Malaria parasite P. yoelii Genotype Disrupted Gene model (rodent): PY17X_0304500; Gene model (P.falciparum): PF3D7_0206200; Gene product: pantothenate transporter (PAT) Transgene Transgene not Plasmodium: eGFP
Promoter: Gene model: PYYM_0712000; Gene model (P.falciparum): Not available; Gene product: heat shock protein, putative (HSP70)
3'UTR: Gene model: Not available; Gene product: Not available
Replacement locus: Gene model: PY17X_0304500; Gene product: pantothenate transporter (PAT)
Phenotype Oocyst; Sporozoite;
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RMgm-1099Malaria parasite P. yoelii Genotype Disrupted Gene model (rodent): PY17X_0306600; Gene model (P.falciparum): PF3D7_0208900; Gene product: 6-cysteine protein (P230p; 230p) Transgene Transgene not Plasmodium: eGFP
Promoter: Gene model: PYYM_0712000; Gene model (P.falciparum): Not available; Gene product: heat shock protein, putative (HSP70)
3'UTR: Gene model: Not available; Gene product: Not available
Replacement locus: Gene model: PY17X_0306600; Gene product: 6-cysteine protein (P230p; 230p)
Phenotype No phenotype has been described
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RMgm-1100Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1411100; Gene model (P.falciparum): PF3D7_1312600; Gene product: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, putative (BCKDHA; BCKDH-E1a) Phenotype Asexual bloodstage; Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-1101Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1411100; Gene model (P.falciparum): PF3D7_1312600; Gene product: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, putative (BCKDHA; BCKDH-E1a)
Details mutation: the endogenous bckdh gene is replaced by the P. falciparum bckdh gene
Phenotype No phenotype has been described
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RMgm-1102Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_0931200; Gene model (P.falciparum): PF3D7_1116800; Gene product: heat shock protein 101 | chaperone protein ClpB2 (HSP101)
Details mutation: The hsp101 promoter modified to contain a tet-inducible promoter and TRAD4 activating domain
Details conditional mutagenesis: Downregulation of HSP101 expression by addition of the tetracycline derivative ATc
Phenotype Asexual bloodstage;
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RMgm-1103Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_1349800; Gene model (P.falciparum): PF3D7_1335900; Gene product: thrombospondin-related anonymous protein | sporozoite surface protein 2 (sporozoite surface protein 2; SSP2; SSP-2; TRAP)
Details mutation: The endogenous P. berghei trap gene replaced with the ortholog of P. vivax
Phenotype Sporozoite; Liver stage;
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RMgm-1104Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_0403200; Gene model (P.falciparum): PF3D7_0304600; Gene product: circumsporozoite (CS) protein (CSP)
Details mutation: The P. berghei csp gene replaced with (part of) the csp gene (210 allele) of P. vivax PVP01_0835600)
Phenotype No phenotype has been described
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RMgm-1105Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1126200; Gene model (P.falciparum): PF3D7_0627500; Gene product: protein DJ-1 (DJ1) Transgene Transgene not Plasmodium: GFP
Promoter: Gene model: PBANKA_1126200; Gene model (P.falciparum): PF3D7_0627500; Gene product: protein DJ-1 (DJ1)
3'UTR: Gene model: Not available; Gene product: Not available (P. vivax actin)
Replacement locus: Gene model: PBANKA_1126200; Gene product: protein DJ-1, putative (DJ1)
Phenotype Asexual bloodstage; Oocyst;
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RMgm-1106Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0302500; Gene model (P.falciparum): PF3D7_0204700; Gene product: hexose transporter (hexose transporter 1, HT1; PfHT1, PfHT, PbHT, PbHT1)
Name tag: c-myc
Phenotype Gametocyte/Gamete;
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RMgm-1107Malaria parasite P. yoelii Genotype Disrupted Gene model (rodent): PY17X_1427200; Gene model (P.falciparum): PF3D7_0812300; Gene product: sporozoite surface protein 3, putative (SSP3) Transgene Transgene not Plasmodium: GFPmut2
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: Not available; Gene product: Not available
Replacement locus: Gene model: PY17X_1427200; Gene product: sporozoite surface protein 3, putative (SSP3)
Phenotype Sporozoite; Liver stage;
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RMgm-1108Malaria parasite P. yoelii Genotype Tagged Gene model (rodent): PY17X_1427200; Gene model (P.falciparum): PF3D7_0812300; Gene product: sporozoite surface protein 3, putative (SSP3)
Name tag: 4xMyc and 3xHA
Phenotype Sporozoite;
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RMgm-1109Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0106200; Gene model (P.falciparum): PF3D7_0607600; Gene product: spindle assembly abnormal protein 6, putative (SAS6) Phenotype Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-1110Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0106200; Gene model (P.falciparum): PF3D7_0607600; Gene product: spindle assembly abnormal protein 6, putative (SAS6) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-1111Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0106200; Gene model (P.falciparum): PF3D7_0607600; Gene product: spindle assembly abnormal protein 6, putative (SAS6)
Name tag: c-myc
Phenotype Gametocyte/Gamete;
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RMgm-1112Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: Ovalbumin (OVA ) fused to mCherry
Promoter: Gene model: PBANKA_0711900; Gene model (P.falciparum): PF3D7_0818900; Gene product: heat shock protein 70 (HSP70)
3'UTR: Gene model: PBANKA_0711900; Gene product: heat shock protein 70 (HSP70)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Asexual bloodstage; Gametocyte/Gamete; Liver stage;
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RMgm-1113Malaria parasite P. berghei Genotype Mutated Gene model (rodent): PBANKA_0813000; Gene model (P.falciparum): PF3D7_0911900; Gene product: falstatin | inhibitor of cysteine proteases (falstatin; PbICP; ICP)
Details mutation: The mutant contains a FRTed ORF of the icp locus
Details conditional mutagenesis: The ORF of icp is removed in the sporozoite stage by the Flp/FRT system.
Transgene Transgene not Plasmodium: FlpL recombinase of yeast (FlpL)
Promoter: Gene model: PBANKA_0501200; Gene model (P.falciparum): Not available; Gene product: early transcribed membrane protein up-regulated in infective sporozoites
3'UTR: Gene model: PBANKA_1349800; Gene product: sporozoite surface protein 2 thrombospondin-related anonymous protein (sporozoite surface protein 2; SSP2; SSP-2)
Insertion locus: Gene model: PBANKA_0501200; Gene product: early transcribed membrane protein up-regulated in infective sporozoites
Phenotype Sporozoite; Liver stage;
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RMgm-1114Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0813000; Gene model (P.falciparum): PF3D7_0911900; Gene product: falstatin | inhibitor of cysteine proteases (falstatin; PbICP; ICP) Phenotype Asexual bloodstage; Sporozoite; Liver stage;
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RMgm-1115Malaria parasite P. berghei Genotype Other modification Gene model (rodent): PBANKA_0306000; Gene model (P.falciparum): PF3D7_0208900; Gene product: 6-cysteine protein (P230p;)
Details modification: The GIMO-mutant contains the hdhfr::yfcu positive-negative selection marker in the silent 230p locusPhenotype No phenotype has been described
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RMgm-1116Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: Ovalbumin (OVA ) fused to HEP17/EXP1
Promoter: Gene model: PBANKA_0926700; Gene model (P.falciparum): PF3D7_1121600; Gene product: exported protein 1 | circumsporozoite-related antigen | parasitophorous vacuole membrane antigen QF 116 (HEP17; EXP1)
3'UTR: Gene model: PBANKA_0926700; Gene product: exported protein 1, putative circumsporozoite-related antigen (HEP17; EXP1)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Asexual bloodstage; Gametocyte/Gamete; Liver stage;
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RMgm-1117Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: Ovalbumin (OVA ) fused to mCherry
Promoter: Gene model: PBANKA_0711900; Gene model (P.falciparum): PF3D7_0818900; Gene product: heat shock protein 70 (HSP70)
3'UTR: Gene model: PBANKA_0711900; Gene product: heat shock protein 70 (HSP70)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Asexual bloodstage;
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RMgm-1118Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: Ovalbumin (OVA ) fused to HEP17/EXP1
Promoter: Gene model: PBANKA_0926700; Gene model (P.falciparum): PF3D7_1121600; Gene product: exported protein 1 | circumsporozoite-related antigen | parasitophorous vacuole membrane antigen QF 116 (HEP17; EXP1)
3'UTR: Gene model: PBANKA_0926700; Gene product: exported protein 1, putative circumsporozoite-related antigen (HEP17; EXP1)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Asexual bloodstage;
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RMgm-1119Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_0402700; Gene model (P.falciparum): PF3D7_0304100; Gene product: inner membrane complex protein 1e, putative (IMC1e; ALV2) Phenotype No phenotype has been described
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RMgm-1120Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1202000; Gene model (P.falciparum): PF3D7_1003600; Gene product: inner membrane complex protein 1c, putative (IMC1c; ALV5) Phenotype No phenotype has been described
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RMgm-1121Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0402700; Gene model (P.falciparum): PF3D7_0304100; Gene product: inner membrane complex protein 1e, putative (IMC1e; ALV2)
Name tag: GFP
Phenotype Asexual bloodstage; Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-1122Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1202000; Gene model (P.falciparum): PF3D7_1003600; Gene product: inner membrane complex protein 1c, putative (IMC1c; ALV2)
Name tag: mCherry
Phenotype Asexual bloodstage; Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-1123Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1202000; Gene model (P.falciparum): PF3D7_1003600; Gene product: inner membrane complex protein 1c, putative (IMC1c; ALV2)
Name tag: GFP
Phenotype Asexual bloodstage; Fertilization and ookinete; Oocyst; Sporozoite;
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RMgm-1124Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: OVA (AA 142-389)
Promoter: Gene model: PBANKA_0501200; Gene model (P.falciparum): Not available; Gene product: early transcribed membrane protein up-regulated in infective sporozoites (UIS4; ETRAMP10.3)
3'UTR: Gene model: Not available; Gene product: Not available
Insertion locus: Gene model: Not available; Gene product: Not available (small subunit ribosomal rna gene (c- or d-type unit))
Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Sporozoite; Liver stage;
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RMgm-1125Malaria parasite P. berghei Genotype Transgene Transgene not Plasmodium: OVA (AA 142-389) fused to export motifs
Promoter: Gene model: PBANKA_0501200; Gene model (P.falciparum): Not available; Gene product: early transcribed membrane protein up-regulated in infective sporozoites (UIS4; ETRAMP10.3)
3'UTR: Gene model: Not available; Gene product: Not available
Insertion locus: Gene model: Not available; Gene product: Not available (small subunit ribosomal rna gene (c- or d-type unit))
Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Sporozoite; Liver stage;
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RMgm-1126Malaria parasite P. berghei Genotype Genetic modification not successful Mutated Gene model (rodent): PBANKA_1107100; Gene model (P.falciparum): PF3D7_0507500; Gene product: subtilisin-like protease 1 (SUB1)
Details mutation: N-terminal deletion ((a-helix + belt loop, residues 21–109)
Phenotype No phenotype has been described
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RMgm-1127Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1225400; Gene model (P.falciparum): PF3D7_0805200; Gene product: gamete release protein, putative | IMC-associated apicomplexan protein, putative (GAMER) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite; Liver stage;
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RMgm-1128Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0603900; Gene model (P.falciparum): PF3D7_1205200; Gene product: HAD domain ookinete protein, putative | MORN1-associated HAD phosphatase, putative (HADO) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Gametocyte/Gamete; Fertilization and ookinete; Oocyst; Sporozoite; Liver stage;
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RMgm-1130Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1205900; Gene model (P.falciparum): PF3D7_1007700; Gene product: AP2 domain transcription factor AP2-I (ApiAP2; PfAP2-T (expressed in the trophozoite stage)) Phenotype No phenotype has been described
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RMgm-1131Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1319100; Gene model (P.falciparum): PF3D7_1455400; Gene product: hemolysin III (HlyIII) Phenotype No phenotype has been described
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RMgm-1132Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1362500; Gene model (P.falciparum): PF3D7_1305600; Gene product: site-2 protease S2P, putative (MEMP1) Phenotype Oocyst;
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RMgm-1133Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1404100; Gene model (P.falciparum): PF3D7_1305600; Gene product: site-2 protease S2P, putative (S2P) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Asexual bloodstage; Liver stage;
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RMgm-1134Malaria parasite P. berghei Genotype Genetic modification not successful Disrupted Gene model (rodent): PBANKA_1032100; Gene model (P.falciparum): PF3D7_1410400; Gene product: rhoptry-associated protein 1 (RAP1) Phenotype No phenotype has been described
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RMgm-1135Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1110500; Gene model (P.falciparum): PF3D7_0511000; Gene product: translationally-controlled tumor protein homolog | histamine-releasing factor (Histamine releasing factor (HRF)) Transgene Transgene not Plasmodium: GFP (gfp-mu3)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Liver stage;
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RMgm-1136Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1412600; Gene model (P.falciparum): PF3D7_1314200; Gene product: telomerase reverse transcriptase Phenotype Asexual bloodstage;
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RMgm-1137Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0506500; Gene model (P.falciparum): PF3D7_1022300; Gene product: ZIP domain-containing protein, putative (ZIP domain-containing protein, ZIPCO) Phenotype Liver stage;
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RMgm-1138Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0506500; Gene model (P.falciparum): PF3D7_1022300; Gene product: ZIP domain-containing protein, putative (ZIP domain-containing protein, ZIPCO)
Name tag: HA
Phenotype Liver stage;
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RMgm-1139Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_1141300; Gene model (P.falciparum): PF3D7_1365500; Gene product: aminomethyltransferase, mitochondrial, putative | glycine cleavage system T protein, putative (GCVT) Phenotype No phenotype has been described
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RMgm-1140Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0902100; Gene model (P.falciparum): PF3D7_1147000; Gene product: sporozoite and liver stage asparagine-rich protein | sporozoite asparagine-rich protein Transgene Transgene not Plasmodium: A fusion of GFP (gfp-mu3) and Luciferase Firefly (LucIAV)
Promoter: Gene model: PBANKA_1133300; Gene model (P.falciparum): PF3D7_1357100; Gene product: elongation factor 1-alpha (eef1a)
3'UTR: Gene model: PBANKA_0719300; Gene product: bifunctional dihydrofolate reductase-thymidylate synthase, putative (dhfr/ts)
Replacement locus: Gene model: PBANKA_0306000; Gene product: 6-cysteine protein (230p)
Phenotype Liver stage;
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RMgm-1141Malaria parasite P. berghei Genotype Disrupted Gene model (rodent): PBANKA_0808100; Gene model (P.falciparum): PF3D7_0317100; Gene product: 6-cysteine protein (B9) Disrupted Gene model (rodent): PBANKA_0902100; Gene model (P.falciparum): PF3D7_1147000; Gene product: sporozoite and liver stage asparagine-rich protein | sporozoite asparagine-rich protein Phenotype Liver stage;
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RMgm-1142Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0821200; Gene model (P.falciparum): PF3D7_0920300; Gene product: conserved Plasmodium protein, unknown function
Name tag: GFP
Phenotype Gametocyte/Gamete; Fertilization and ookinete;
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RMgm-1143Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_0107700; Gene model (P.falciparum): PF3D7_0609100; Gene product: zinc transporter ZIP1, putative
Name tag: GFP
Phenotype Gametocyte/Gamete; Fertilization and ookinete;
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RMgm-1144Malaria parasite P. berghei Genotype Tagged Gene model (rodent): PBANKA_1114100; Gene model (P.falciparum): PF3D7_0514500; Gene product: conserved Plasmodium membrane protein, unknown function
Name tag: GFP
Phenotype Gametocyte/Gamete; Fertilization and ookinete;
Conceptual design of the database: Dr. C.J. Janse (Leiden Malaria Research Group, Leiden, The Netherlands).
Technical design and realization: 
StudioDrie; S. Mededovic and A. van Wigcheren
StudioDrie; S. Mededovic and A. van Wigcheren