Mutant/mutation
The mutant lacks expression of LAP5 (FNPA)

Protein (function)
The lap5 gene is a member of a small conserved gene family, encoding proteins with multiple adhesive domains, for example a Lgl1 (LCCL)-lectin adhesive domain. In P. falciparum the LCCL domain-containing proteins are termed PfCCp's. LAP5 lacks the LCCL domain but has a domain architecture that indicates a vertical relationship with
PfCCp5/LAP3. It contains a fibronectin type 2 domain and an anthrax protective antigen N-terminal domain (Lavazec, C. et al., 2008, Mol. Biochem. Parasitol. 163, 1-7).
The LAP5 (FNPA) protein is detected in a proteome analysis of ookinetes.

Phenotype
Phenotype analyses indicate a role during oocyst development and sporozoite formation/production (see also additional information).

Additional information
Crossings of the mutant females with wild type males did not rescue the formation/production of sporozoites. Crossing of the mutant males with wild type females resulted in wild type production of sporozoites that were infectious to C57BL/6 mice.
Crossings between other mutants have shown that wild type males can rescue defects in females that affect ookinete invasion and traversal of the midgut wall at 18-30 hours after fertilization. The lack of rescue of the ∆lap5 mutant phenotype by crossing of mutant females with wild type males is suggestive of a role of LAP5 within a few hours after fertilization.

Other members of the LAP/CCp family of proteins have been analyzed by targeted gene disruption. A number of mutants lacking expression of these proteins show a comparable defect in development of oocysts and formation of sporozoites (RMgm-113, RMgm-114, RMgm-115: LAP1/PbSLAP/PbSR/CCp3; RMgm-118: LAP2/CCp1; RMgm-119: LAP4/CCp2; RMgm-120: LAP6, CCp4).
  

Other mutants