Mutant/mutation
The mutant lacks expression of RAP1

Protein (function)
In P. falciparum a low-molecular-weight protein complex, consisting of three non-covalently linked members, RAP1, RAP2 and RAP3 localises to the rhoptries (rhoptry bulb) of merozoites. RAP2 and RAP3 are encoded by adjacent genes, organised in a head to tail fashion. Both rap2 and rap3 show a high homology with the single copy, syntenic gene, rap2/3 of P. berghei.

Phenotype
Parasitemia in Δrap1 parasite-infected mice was similar to that in control-parasite-infected mice until day 7 p.i.. Evidence is presented for the absence of experimental cerebral complications in B6 mice. Mice infected with Δrap1 parasites survived for longer than did control-parasite-infected mice

Additional information

Other mutants

See link PF3D7_1410400 for other rap1 mutants (unsuccessful attempts to disrupt the rap1 gene and rap1 knock-out mutants with slow growing asexual blood stage phenotype)