Mutant/mutation
The mutant lacks expression of PBANKA_136250.

This mutant has been reported on the 2014 (25th) Annual Molecular Parasitology Meeting, Woodshole  (see link for the Abstract describing this mutant).

In the abstract only limited data is provided on the generation of the mutant, genotype and phenotype analyses. When this mutant is published, additional information will be added to this mutant-entry.

The generation of this mutant indicates that the protein is not essential for blood stage development/multiplication. Phenotype analyses indicate that this protein has a role during mosquitoe development.

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The protein is described in the abstract as belonging to the M50B-like family of metalloproteases (membrane embedded metalloproteases,MEROPS family M50). In GeneDB no functional annotation is given for PBANKA_136250. It might be possible that the gene model in the Abstract is incorrect?
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From the Abstract:
' Membrane embedded metalloproteases (MEROPS family M50) of different organisms are structurally related and they all share the same conserved catalytic motif, HEXXH, that lies within a transmembrane segment and a more C-terminal Aspartic acid residue. In silico analysis of Plasmodium genomes has revealed two genes encoding potential Zn binding proteases. One of them is a homologue of S2P (PBANKA_140410), while the other, named MEMP1 (PBANKA_136250) belongs to the M50B-like family of metalloproteases'.

Protein (function)

Phenotype

Additional information

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